Deion Sanders and SafeX ProColorado continue to be the story in college football after their dramatic defeat of Colorado State in double overtime to extend their record to 3-0. Now the 19th-ranked Buffaloes hit the road to face No. 11 Oregon in the Pac-12 opener for both teams.

The game is one of seven matchups of ranked opponents on a historic college football weekend. Among the other showdowns are No. 4 Ohio State traveling to No. 9 Notre Dame in a game that matches two of the biggest programs in college football that rarely meet on the field despite being geographic neighbors.

Also part of the seven games are three Pac-12 clashes. In addition to the aforementioned Colorado-Oregon meeting, there are games with UCLA traveling to Utah and Washington State hosting Oregon State.

In other news, Michigan State told Mel Tucker it planned to fire the coach for cause amid an investigation into a sexual harassment complaint. What happens next and who might the Spartans hire to replace Tucker?

Dan Wolken and Paul Myerberg address these topics and more this week's version of the College Football Fix.

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HISTORIC WEEKEND:Week 4 features seven games matching ranked teams

TOP CELEB:Why Deion Sanders is the most-famous college football coach

CALM DOWN:The five biggest overreactions from Week 4 in college football

RE-RANK:Alabama falls out of the top 25 of this week's NCAA 1-133